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Real members of myPNHteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

What research is being done to show a linkage between covid infections and pnh exacerbation or pnh origination?

A myPNHteam Member asked a question 💭
Toronto, ON
August 7, 2025
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What Causes PNH? 5 Facts and Risk Factors Read Article...
A myPNHteam Member

Thanks, this makes sense.

September 29, 2025
A myPNHteam Member

Yes, paroxysmal nocturnal hemoglobinuria (PNH) and COVID-19 are linked in several ways, primarily because the inflammation caused by a SARS-CoV-2 infection can trigger or worsen the symptoms of PNH. The activation of the complement system is the key physiological link between the two diseases

September 23, 2025
A myPNHteam Member

If a weekend immune system causes the abnormal cells to grow would it not there for a follow that a covid infection would exacerbate pnh

August 7, 2025
myPNHteam

Based on the provided search results, there is no information about research linking COVID-19 infections to either PNH exacerbation or origination. What is known is that PNH is caused by random genetic mutations, specifically in the PIGA gene, and these mutations are not linked to any known environmental factors.

The only Show Full Answer

Based on the provided search results, there is no information about research linking COVID-19 infections to either PNH exacerbation or origination. What is known is that PNH is caused by random genetic mutations, specifically in the PIGA gene, and these mutations are not linked to any known environmental factors.

The only established risk factor for developing PNH is having aplastic anemia. About 1 in 10 people with aplastic anemia will eventually develop PNH. If you're concerned about COVID-19's impact on your PNH, it's important to work closely with your healthcare team and maintain regular follow-up visits to monitor your condition and ensure your treatments are working effectively.

August 7, 2025

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